Universität Bonn

Institute for Physiology

Malek-Mohammadi Laboratory

Malek-Mohammadi Laboratory

Our group is interested in understanding the molecular mechanism underlying cardiac regeneration ability of neonatal mice with the future aim of developing therapeutic targets to expand the regenerative window, prevent cardiovascular disease or treat patients in the future

Dr. rer. nat. Mona Malek-Mohammadi

+49 (0) 228-6885 216

Leader of the labratory

Life & Brain Center

Venusberg-Campus 1

53127 Bonn

+49 (0) 228-6885 216

Forschung

Cardiovascular regeneration

The neonatal mice heart has fascinating plasticity, which enables them to regenerate the heart after an injury or adapt to pressure overload. This ability, however, is lost 7 days after birth when cardiomyocytes permanently exit the cell cycle. Recent work has led to a major paradigm shift regarding the effect of pressure overload on neonatal cardiomyocytes. By establishing a neonatal model of pressure overload (nTAC) I was able to show that pressure overload enhances cardiomyocyte proliferation rather than leading to cell cycle arrest in neonatal mice

Echocardiography of 7-day-old mice

Our lab is highly specialized in performing different types of neonatal and adult cardiac surgeries (cryoinjury, LAD ligation, and nTAC) as well as post-cardiac monitoring using Doppler flow velocity measurements and echocardiography (2D, 3D, 4D)

a) Position of the transducer on the mice for long axis view.

b) Long axis view of the heart.

c) Position of the transducer on the mice for short axis view.

d) Short axis view of the heart.

e) Position of the transducer on the mice for aortic arch visualization.

f) Captured image of aortic arch and ligature.

M. Malek Mohammadi, et al, Nat Protoc, 2020

Echocardiography of 7-day-old mice
© Malek-Mohammadi
Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Malk-Mohamadi

Neonatal model of transverse aortic constriction surgery (nTAC)

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Malek-Mohammadi

4D Echocardiography

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Malk-Mohammadi

4D Volume assessment of the heart

Leader of the lab

Avatar Malek-Mohammadi

Dr. rer. nat. Mona Malek-Mohammadi

PhD

+49 (0) 228-6885 216

Leiterin der AG

+49 (0) 228-6885 216

Assistence

Research assistants / postdocs

Avatar Ebach

Dr. med Fabian Ebach

+49 228 6885 212

+49 228 6885 212

PhD students

Avatar Nicke

Julia Nicke

MSc. Biology

+49 228 6885 221

+49 228 6885 221

Avatar Djabour

Reda Djabour

+49 228 6885 212

+49 228 6885 212

Alumni

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Publikationen

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  • M. Szaroszyk, B. Kattih, A. Martin-Garrido, F. A. Trogisch, G. M. Dittrich, A. Grund, A. Abouissa, K. Derlin, M. Meier, T. Holler, M. Korf-Klingebiel, K. Völker, T. G.Macedo, C. P. Tortola, M. Boschmann, N. Huang, N. Froese, C.Zwadlo, M. Malek Mohammadi, X. Luo, M. Wagner, J. Cordero, R. Geffers, S. Batkai, Th.Thum, N. Bork, V. O. Nikolaev, O. J. Müller, H. A. Katus, A. El-Armouche, Th. Kraft, J. Springer, G. Dobreva, K. C. Wollert, J. Fielitz, S. von Haehling, M. Kuhn, J. Bauersachs & J.Heineke. Skeletal muscle-derived Musclin protects the heart during pathological overload. Nature communication 2022. 149 (2022).

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  • M. Malek Mohammadi, A. Abouissa, & J. Heineke, A surgical mouse model of neonatal pressure overload by transverse aortic constriction. Nat Protoc (2020)

  • M. Malek Mohammadi, A. Abouissa, A. Isyatul, Y. Xie, J. Cordero, A. Shirvani, A. Gigina, M. Engelhardt, F. Trogisch, R. Geffers, G. Dobreva, J. Bauersachs, J. Heineke. Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI insight 2019 23; 5. pii: 128336.
  • A. Grund, M. Szaroszyk, M. Korf-Klingebiel, M. Malek Mohammadi, F.Trogisch, U. Schrameck, A. Gigina, Ch. Tiedje, M. Gaestel, Th. Kraft, J. Hegermann, S. Batkai, Th. Thum, A. Perrot, C. Remedios, E. Riechert, M. Völkers, Sh. Doroudgar, A. Jungmann, R. Bauer, X. Yin, M. Mayr, K. Wollert, A. Pich, H. Xiao, H. Katus, J. Bauersachs, O. Müller, J. Heineke. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med (2019)11: e10018.
  • Grund A, Szaroszyk M, Döppner JK, M. Malek Mohammadi, Kattih B, Korf-Klingebiel M, Gigina A, Scherr M, Kensah G, Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Müller OJ, Bauersachs J, Heineke J.A gene therapeutic approach to inhibit CIB1 ameliorates maladaptive remodeling in pressure overload. Cardiovasc Res. 2018 1; 115(1):71-82.
  • M. Malek Mohammadi, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol. Med. 2017; 9(2):265-279.
  • Appari M, Breitbart A, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, M. Malek Mohammadi, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res. 2017 6;120(1):66-77
  • Hussain A*, Zhang M*, Üçpunar HK, Svensson T, Quillery E, Gompel N, Ignell R, Grunwald Kadow IC (2016). Ionotropic chemosensory receptors mediate the taste and smell of polyamines. PLoS Biology 14:e1002454. doi:10.1371
    [download]

  • Hussain A*, Üçpunar HK*, Zhang M, Loschek LF, Grunwald Kadow IC (2016).
    Neuropeptides modulate female chemosensory processing upon mating in Drosophila.
    PLoS Biology 14:e1002455. doi: 10.1371
* equal contribution
    [download]

2015

  • Lewis L, Siju KP, Aso Y, Friedrich AB, Bulteel AJB, Rubin GM, Grunwald Kadow IC (2015).
    A higher brain circuit for immediate integration of conflicting sensory information in Drosophila.
    Current Biology PMID: 26299514, doi: 10.1016/j.cub.2015.07.015
    [download]

  • Organisti C, Hein I, Grunwald Kadow IC*, Suzuki T* (2015).
    Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline pathfinding.
    Genes to Cells 20:50-67. doi: 10.1111/gtc.12202. Epub 2014 Nov 30
    [download]

2014

  • Siju KP*, Bräcker LB*, Grunwald Kadow IC (2014).
    Neural mechanisms of context-dependent modification of CO2 avoidance behavior in fruit flies.
    Fly 8:68-74. doi: 10.4161/fly.28000 * equal contribution
    [download]

2013

  • Hartl M, Grunwald-Kadow IC (2013).
    New roles for ‘old’ microRNAs in nervous system function and disease.
    Front Mol Neurosci doi: 10.3389/fnmol.2013.00051
    [download]

  • Bräcker LB*, Siju KP*, Varela N, Zhang M, Aso Y, Vasconcelos ML, Grunwald Kadow IC (2013).
    Essential role of the mushroom body in context-dependent CO₂avoidance in Drososphila.
    Current Biololgy 23(13):1228-34. doi: 10.1016/j.cub.2013.05.029. Epub 2013 Jun 13 * equal contribution
    [download]

  • Hein I, Suzuki T, Grunwald Kadow IC (2013).
    Gogo receptor contributes to retinotopic map formation and prevents R1- photoreceptor axon bundling.
    PLoS One 8(6):e66868. doi: 10.1371/journal.pone.0066868
    [download]

2012

  • Stephan D, Sanchez-Soriano N, Loschek LF, Gerhards R, Gutmann S, Storchova Z, Prokop A and Grunwald Kadow IC (2012).
    Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.
    Journal of Neuroscience 32(46):16080-94
    [download]

  • Otranto D, Cantacessi C, Lia RP, Grunwald Kadow IC, Siju KP, Dantas-Torres F, Máca J (2012).
    First laboratory Culture of Phortica variegata (Diptera, Steganinae), the Thelazia callipaeda Vector.
    Journal of Vector Ecology 37(2): 458-61
    [download]

2011

  • Hartl M, Loschek LF, Stephan D, Siju KP, Knappmeyer C, Grunwald Kadow IC (2011).
    A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation.
    Journal of Neuroscience 31(44): 15660-73
    [download]

2008

  • Cayirlioglu P*, Grunwald Kadow I*, Zhan X, Okamura K, Gunning D, Lai EC, Zipursky SL (2008).
    Hybrid Neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems.
    Science 319: 1256-1260 * equal contribution
    [download]

2007

  • Jones WD, Cayirlioglu P, Grunwald Kadow I, Vosshall LB (2007).
    Two chemosensory receptors together mediate carbon dioxide detection in Drosophila.
    Nature 445: 86-90
    [download]

2001-2004

  • Grunwald IC*, Korte M*, Adelmann G, Plueck A, Kullander K, Adams RH, Frotscher M, Bonhoeffer T, Klein R (2004).
    Hippocampal plasticity requires postsynaptic ephrinBs.
    Nature Neuroscience 7: 33-40 * equal contribution
    [download]

  • Zorner B, Wolfer DP, Brandis D, Kretz O, Zacher C, Madani R, Grunwald I, Lipp HP, Klein R, Henn FA, Gass P (2003).
    Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".
    Biol Psychiatry 54: 972-982 
    [download]

  • Grunwald IC, Klein R (2002).
    Axon guidance: receptor complexes and signaling mechanisms.
    Current Opinion Neurobiology 12: 250-259
    [download]

  • Grunwald IC*, Korte M*, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R (2001)
    Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity.
    Neuron 32: 1027-1040 * equal contribution
    [download]

Reviews

  • Siju KP, De Backer JF, Grunwald Kadow IC. Dopamine modulation of sensory processing and adaptive behavior in flies, Cell and Tissue Research, Special Issue on Olfactory Coding and Circuitries, in press.

  • Grunwald Kadow, IC (2018). State-dependent plasticity of innate behavior in fruit flies. Current Opinion in Neurobiology Volume 54, online [link]

  • Sayın, S*, Boehm, AC*, Kobler, J*, De Backer, JF, and Grunwald Kadow, IC (2018).
    Internal state dependent odor processing and perception - the role of neuromodulation in the fly olfactory system.
    Frontiers of Cellular Neuroscience, in press. * equal contribution [link]

  • Gaspar Jekely, Sarah Melzer, Isabel Beets, Ilona C. Grunwald Kadow, Joris Koene, Sara Haddad, and Lindy Holden-Dye.
    The long and the short of it: A perspective on peptidergic regulation of circuits and behaviour.
    Journal of Experimental Biology  2018  221: jeb166710 doi: 10.1242/jeb.166710  Published 8 February 2018 [download]

  • Siju KP, Bräcker LB, Grunwald Kadow IC (2014).
    Neural mechanisms of context-dependent modification of CO2 avoidance behavior in fruit flies.
    Fly 8:68-74. doi: 10.4161/fly.28000 [download]

  • Hartl M, Grunwald-Kadow IC (2013).
    New roles for ‘old’ microRNAs in nervous system function and disease.
    Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2013.00051
    [download]

  • Grunwald IC, Klein R (2002).
    Axon guidance: receptor complexes and signaling mechanisms.
    Current Opinion Neurobiology 12: 250-259
    [download]