Malek-Mohammadi Laboratory
Our group is interested in understanding the molecular mechanism underlying cardiac regeneration ability of neonatal mice with the future aim of developing therapeutic targets to expand the regenerative window, prevent cardiovascular disease or treat patients in the future
Dr. rer. nat. Mona Malek-Mohammadi
Leader of the labratory
Life & Brain Center
Venusberg-Campus 1
53127 Bonn
Forschung

© Malek-Mohammadi
4D Echocardiography

© Malk-Mohammadi
4D Volume assessment of the heart
Leader of the lab
Dr. rer. nat. Mona Malek-Mohammadi
PhD
Leiterin der AG
Assistence
Research assistants / postdocs
PhD students
Alumni
2022
- M. Szaroszyk, B. Kattih, A. Martin-Garrido, F. A. Trogisch, G. M. Dittrich, A. Grund, A. Abouissa, K. Derlin, M. Meier, T. Holler, M. Korf-Klingebiel, K. Völker, T. G.Macedo, C. P. Tortola, M. Boschmann, N. Huang, N. Froese, C.Zwadlo, M. Malek Mohammadi, X. Luo, M. Wagner, J. Cordero, R. Geffers, S. Batkai, Th.Thum, N. Bork, V. O. Nikolaev, O. J. Müller, H. A. Katus, A. El-Armouche, Th. Kraft, J. Springer, G. Dobreva, K. C. Wollert, J. Fielitz, S. von Haehling, M. Kuhn, J. Bauersachs & J.Heineke. Skeletal muscle-derived Musclin protects the heart during pathological overload. Nature communication 2022. 149 (2022).
2020
-
M. Malek Mohammadi, A. Abouissa, & J. Heineke, A surgical mouse model of neonatal pressure overload by transverse aortic constriction. Nat Protoc (2020)
2019
- M. Malek Mohammadi, A. Abouissa, A. Isyatul, Y. Xie, J. Cordero, A. Shirvani, A. Gigina, M. Engelhardt, F. Trogisch, R. Geffers, G. Dobreva, J. Bauersachs, J. Heineke. Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI insight 2019 23; 5. pii: 128336.
- A. Grund, M. Szaroszyk, M. Korf-Klingebiel, M. Malek Mohammadi, F.Trogisch, U. Schrameck, A. Gigina, Ch. Tiedje, M. Gaestel, Th. Kraft, J. Hegermann, S. Batkai, Th. Thum, A. Perrot, C. Remedios, E. Riechert, M. Völkers, Sh. Doroudgar, A. Jungmann, R. Bauer, X. Yin, M. Mayr, K. Wollert, A. Pich, H. Xiao, H. Katus, J. Bauersachs, O. Müller, J. Heineke. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med (2019)11: e10018.
2018
- Grund A, Szaroszyk M, Döppner JK, M. Malek Mohammadi, Kattih B, Korf-Klingebiel M, Gigina A, Scherr M, Kensah G, Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Müller OJ, Bauersachs J, Heineke J.A gene therapeutic approach to inhibit CIB1 ameliorates maladaptive remodeling in pressure overload. Cardiovasc Res. 2018 1; 115(1):71-82.
2017
- M. Malek Mohammadi, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol. Med. 2017; 9(2):265-279.
- Appari M, Breitbart A, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, M. Malek Mohammadi, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res. 2017 6;120(1):66-77